Palm Fruit bottle and liquid capsules sitting on counter top next to plate of fruit.

Introducing the new Palm Fruit™ liquid capsules

Published:
Jan 30, 2017
Updated:
Oct 16, 2021
Table of Contents

Intro

The Palm Fruit™ liquid capsules are finally here.

Although many customers love our Palm Fruit™ powder, it’s been a recurring complaint that it’s difficult to use. The powder tends to stain everything bright orange because of the carotenoids, including your fingers, teeth, and tongue especially if you happen to take Palm Fruit powder straight to the mouth.

So we knew that we needed to get Palm Fruit™ into a pill, but why a liquid filled capsule you might ask?

To answer that, let’s go all the way back to 2015...

Back to the drawing board

After many months of working with our suppliers and manufacturers, we realized that we could secure a significant cost reduction by eliminating the spray-drying process required to turn the red palm oil liquid extract into a powder. Rather than processing the liquid extract into a powder, we could just directly encapsulate it.

In fact, cutting the spray-drying process also resulted in less degradation of the active ingredients and gave us such a significant cost reduction that it almost entirely offset the increased cost of encapsulation.

So going to liquid filled capsules was a win-win for everyone, but there were other improvements we wanted to make as well, so we kept going.

The five major improvements

Moving to liquid capsules gave us the opportunity to make some pretty major improvements, most notably:

  1. Liquid filled vegetarian capsules for more convenience
  2. Increased dosage of palm-based carotenoids and tocochromanols (tocotrienols and tocopherols)
  3. Addition of 100 mg of sesame seed extract (90% sesamin)
  4. Improved packaging for better protection of the active ingredients
  5. Removal of all additives and preservatives

Even with all of these improvements, we are able to keep the product price the same as the original Palm Fruit™ powder ($49.99 USD).

Now let’s talk about each of the major improvements.

Liquid filled vegetarian capsules

For our liquid capsules, we collaborated with the world leader in liquid encapsulation, Capsugel®.

For starters, we used a vegetarian capsule made from a plant-based material known as hypromellose (i.e., hydroxypropyl methylcellulose). This material is derived from plant-based cellulose; it is 100% free of animal product, and is kosher and halal certified.

Not only do the capsules look extremely cool, but they help protect the active ingredients from degradation. During encapsulation, to prevent exposure to oxygen, the fill tanks are flushed with food-grade nitrogen, and the empty capsule bodies are blanketed with nitrogen on the fill-belt to remove oxygen from the empty headspace. This prevents oxidation of the active phytonutrients until they're bottled into low-oxygen packaging.

Finally, the two-piece capsule is hermetically joined together with a water-seal. The end result is a highly durable leak-proof capsule.

Unlike softgels, the liquid capsules are resistant to softening and/or hardening, allowing them to travel through harsh environments without sticking together or cracking.

Increased dosage of carotenoids and tocochromanols

To achieve a higher concentration of carotenoids and tocochromanols we collaborated with our palm fruit phytonutrient producer Excelvite. (Excelvite is the only GMP-certified and FDA-inspected palm phytonutrient supplier in the world).

Our first requirement was to boost the tocochromanols up to 160 mg from 154 mg in the powder version. The small bump in tocochromanols was to ensure we were meeting the dose used in the human clinical study that shows reduced DNA damage. [1] We also wanted to boost the carotenoids up from 10 mg to 30 mg. This 300% increase in carotenoids would ensure we were delivering the optimal dose of carotenoids for anti-aging benefits and enhanced sun production. [2] [3] [4]

As a result of our new stringent requirements, Excelvite had to make a custom red palm fruit extract exclusively for Botanical Craft, making Palm Fruit™ liquid capsules the most concentrated supplement of tocochromanols and carotenoids ever to be produced.

Addition of 100 mg of sesame seed extract (90% sesamin)

We wanted to enhance the benefits of Palm Fruit™ ever further but we knew that increasing the dose of tocochromanols (vitamin E) would not be an effective way of accomplishing this for a couple of reasons.

Firstly, there is an interesting paradox with vitamin E: The more you take, the less you get.

For example, supplementing with 546 mg/day of vitamin E (α-tocopherol) does not result in significantly greater tissue or plasma concentrations than 136 mg/day. [5] Even a dose as high as 1,320 mg/day α-tocopherol results in only slightly higher plasma concentrations compared to a 440 mg/day dose. [6]

Once the body senses sufficient vitamin E levels (about 9 mg α-tocopherol per day) the liver starts increasing production of the CYP4F enzyme to clear out excess vitamin E. [7] [8] [9] The more vitamin E taken, the faster the body removes it, to the point where the amount of vitamin E excreted nearly equals the amount taken once the dose exceeds about 200 mg/day. [7] [8] [9] In addition to wasting money, the other unfortunate side-effect of taking more than 200 mg/day of vitamin E, is that excessive production of CYP4F also clears out vitamin K from the body. [10]

Therefore, it makes little sense for anyone to supplement with more than 200 mg/day of vitamin E. Rather, it is safer and more efficient to control CYP4F activity in order to achieve greater vitamin E related benefits. Clinical research has demonstrated that suppressing CYP4F increases vitamin E concentrations, and amplifies the benefits from vitamin E. [11] [12] [13] [14] [15]

This is where sesamin comes in; it is the most potent naturally occurring CYP4F inhibitor. [15] Several animal and human studies have shown that it safely increases the body’s retention of vitamin E. [11] [12] [13] [14] [15] [16] In fact, in humans, after only 24 hours of taking sesamin (94 mg), plasma levels of vitamin E (γ-tocopherol) increase by about 30%. [16]

Although it took many months of searching and lab testing, we finally found an extremely high quality sesame seed extract. The sesame seeds are grown in the Chinese province of Inner Mongolia, which is known as the grassland empire with high quality air and soil. We also made sure our sesame seed extract was free of pesticides, dangerous solvents, and unwanted heavy metals, which we verified with extensive testing at Eurofins and Micro Quality Labs Inc.

Improved packaging for better protection of the active ingredients

Through our follow-up stability testing of our original Palm Fruit™ powder, we found the active compounds (e.g., carotenoids) were degrading by about 10% each year as a result of oxidation, even in the sealed HDPE container. It became clear that our packaging needed an upgrade.

Minimizing oxygen exposure is the most important element for maximizing stability, potency, and shelf-life. Even with exposure to high temperatures and/or UV light, an ultra low oxygen (≤0.1%) concentration will almost completely mitigate the degradation. [19] [20] [21] [22] And even though our new capsules are oxygen resistant and help protect the active compounds, oxygen can still penetrate the sealed capsule shell slowly over time. [23] [24] In addition, oxygen readily penetrates through most plastics.

Indeed, maintaining a zero-oxygen environment is much more difficult that it sounds.

After several months of collaboration with Mitsubishi Chemical corporation we developed a packaging system that maintains a ultra low oxygen concentration for a minimum of 3 years, utilizing the following components:

  • PET bottle with a low oxygen transmission rate
  • Ageless® ZM-1 oxygen absorber with 100 cc oxygen absorption capacity
  • Heat induction sealed U5 LP-M foil liner with zero oxygen permeability

This makes the new Palm Fruit™ capsules the freshest red palm fruit extract in the world, and perhaps the freshest phytonutrient supplement in the world.

Removal of all additives and chemical preservatives

By upgrading to liquid capsules we were able to remove all flavors, stabilizers, binders, and flow agents. And by upgrading the packaging we were able to avoid chemical preservatives. [22]

The new Palm Fruit™ liquid capsules are vegan certified, Non-GMO, and free of all harmful pesticides, heavy metals, and additives.

Why do the Supplement Facts look different?

Because of recent changes in food labeling laws, vitamin A must now be declared based on retinol activity equivalents (RAE) with the new RDI of 900 mcg RAE vitamin A replacing the older 5,000 IU RDI. [25] Accordingly, vitamin E must now be declared based on milligrams of α-tocopherol with the new RDI of 15 mg vitamin E replacing the older 30 IU RDI. [25]

In addition to these changes, we no longer declare the mg quantity of each individual tocotrienol and tocopherol in the Supplement Facts. Instead, we declare the total tocochromanols, which is much easier to maintain from a GMP compliance point of view as it allows for slight natural variance between the individual tocochromanols from batch to batch.

Man comparing the old and new Palm Fruit supplement facts
The new Palm Fruit™ liquid capsules contain 300% more carotenoids and 100 mg of sesame seed extract (90% sesamin) to further enhance the anti-aging benefits.

Are there any downsides with the new capsules?

No, but we should mention one thing:

Since we have removed all food-grade emulsifiers from the liquid capsules, it is now recommended to take Palm Fruit™ liquid capsules with a meal for the best absorption of the fat soluble phytonutrients. And it’s best that the meal contains at least 5 g of fat. [26] [27] [28]

How many capsules should I take?

We recommend one (1) capsule for every 125lbs (57 kg) of body weight.

Therefore, an adult that weighs between 126-250 lbs (57-113 kg) should take two (2) capsules per day.

What happens now with the Palm Fruit™ powder?

The Palm Fruit™ powder has been discontinued. The last batch was produced in March 2016 with an expiration date of March 2018. We will continue to ship this to customers who would like the powder version until our existing supply runs out.

In conclusion

We can say with great confidence that the new Palm Fruit™ is the highest quality red palm oil extract in the world, as well as the undisputed champion in the anti-aging category.

If you haven’t already, be sure to get started on our Palm Fruit™ Subscription Plan. It’s a great way to ensure you have a consistent supply shipped to your door each month. Shipping is always free and you get the discounted price of only $39.99 per month.

Palm Fruit liquid capsule bottle and capsules on counter top
The Palm Fruit™ Subscription Plan can be scheduled with a 30, 45, or 60-day autoship frequency, and shipments can be skipped or suspended anytime.

Questions?

Shoot me an email directly at eric@botanicalcraft.com or post a comment below.

References

[1] Chin S-F, Hamid NAA, Latiff AA, et al. 2007. Reduction of DNA damage in older healthy adults by Tri E tocotrienol supplementation. Nutrition. 24(1):1–10

[2] Césarini JP, Michel L, Maurette JM, et al. 2003. Immediate effects of UV radiation on the skin: modification by an antioxidant complex containing carotenoids. Photodermatol. Photoimmunol. Photomed. 19(4):182–89

[3] Lee J, Jiang S, Levine N, et al. 2000. Carotenoid supplementation reduces erythema in human skin after simulated solar radiation exposure. Proc. Soc. Exp. Biol. Med. 223(2):170–74

[4] Gollnick HPM, Hopfenmüller W, Hemmes C, et al. 1996. Systemic beta carotene plus topical UV-sunscreen are an optimal protection against harmful effects of natural uv-sunlight: results of the Berlin-Eilath study. European journal of dermatology. 6(3)(200-205)

[5] London RS, Sundaram GS, Manimekalai S, et al. 1984. Serum Alpha-Tocopherol Levels in Relation to Serum Lipids and Lipoproteins after Oral Administration of Vitamin E. Karger Publishers

[6] Dimitrov NV, Meyer C, Gilliland D, et al. 1991. Plasma tocopherol concentrations in response to supplemental vitamin e. Am. J. Clin. Nutr. 53(3):723–29

[7] Lebold KM, Ang A, Traber MG, et al. 2012. Urinary α-carboxyethyl hydroxychroman can be used as a predictor of α-tocopherol adequacy, as demonstrated in the energetics study. Am. J. Clin. Nutr. 96(4):801–9

[8] Grebenstein N, Schumacher M, Graeve L, et al. 2014. Α-tocopherol transfer protein is not required for the discrimination against γ-tocopherol in vivo but protects it from side-chain degradation in vitro. Mol. Nutr. Food Res. 58(5):1052–60

[9] Schultz M, Leist M, Petrzika M, et al. 1995. Novel urinary metabolite of alpha-tocopherol, 2,5,7,8-tetramethyl-2(2’-carboxyethyl)-6-hydroxychroman, as an indicator of an adequate vitamin e supply? Am. J. Clin. Nutr. 62(6 Suppl):1527S – 1534S

[10] Tovar A, Ameho CK, Blumberg JB, et al. 2006. Extrahepatic tissue concentrations of vitamin K are lower in rats fed a high vitamin e diet. Nutr. Metab. . 3(1):1–6

[11] Yamada Y, Obayashi M, Ishikawa T, et al. 2008. Dietary tocotrienol reduces UVB-induced skin damage and sesamin enhances tocotrienol effects in hairless mice. J. Nutr. Sci. Vitaminol. . 54(2):117–23

[12] Abe C, Ikeda S, Yamashita K. 2005. Dietary sesame seeds elevate alpha-tocopherol concentration in rat brain. J. Nutr. Sci. Vitaminol. . 51(4):223–30

[13] Yamashita K, Iizuka Y, Imai T, et al. 1995. Sesame seed and its lignans produce marked enhancement of vitamin E activity in rats fed a low alpha-tocopherol diet. Lipids. 30(11):1019–28

[14] Takemoto D, Yasutake Y, Tomimori N, et al. 2015. Sesame lignans and vitamin E supplementation improve subjective statuses and anti-oxidative capacity in healthy humans with feelings of daily fatigue. Glob. J. Health Sci. 7(6):1–10

[15] Wu W-H, Kang Y-P, Wang N-H, et al. 2006. Sesame ingestion affects sex hormones, antioxidant status, and blood lipids in postmenopausal women. J. Nutr. 136(5):1270–75

[16] Frank J, Lee S, Leonard SW, et al. 2008. Sex differences in the inhibition of gamma-tocopherol metabolism by a single dose of dietary sesame oil in healthy subjects. Am. J. Clin. Nutr. 87(6):1723–29

[17] Cooney RV, Custer LJ, Okinaka L, et al. 2001. Effects of dietary sesame seeds on plasma tocopherol levels. Nutr. Cancer. 39(1):66–71

[18] Cornwell DG, Ma J. 2007. Studies in vitamin E: biochemistry and molecular biology of tocopherol quinones. Vitam. Horm. 76:99–134

[19] Jørgensen K, Skibsted LH. 1990. Light sensitivity of carotenoids used as food colours. Z Lebensm Unters Forch. 190(4):306–13

[20] Lee Y-S, Park S-R. 2008. Comparative stability of vit E isomers extracted from unsaponifiable fractions of rice bran oil under various temperature and oxygen conditions. Hangug Jaweon Sigmul Haghoeji. 21(6):435–39

[21] Shahidi F, Amarowicz R, Abou-Gharbia HA, et al. Endogenous antioxidants and stability of sesame oil as affected by processing and storage. J. Am. Oil Chem. Soc. 74(2):143–48

[22] Waterman KC, Roy MC. 2002. Use of oxygen scavengers to stabilize solid pharmaceutical dosage forms: a case study. Pharm. Dev. Technol. 7(2):227–34

[23] Felton LA, Timmins GS. 2006. A nondestructive technique to determine the rate of oxygen permeation into solid dosage forms. Pharm. Dev. Technol. 11(1):141–47

[24] Richardson M, Stegemann S. 2007. Filling two-piece hard gelatin capsules with liquids. Tablets & Capsules, pp. 1–6

[25] Food and Drug Administration. 2016. Food Labeling: Revision of the Nutrition and Supplement Facts Labels; Final Rule. Work. Pap.

[26] Roels OA, Trout M, Dujacquier R. 1958. Carotene balances in boys in ruanda where vitamin A deficiency is prevalent. J. Nutr. 65(1):115–27

[27] Jayarajan P, Reddy V, Mohanram M. 1980. Effect of dietary fat on absorption of beta carotene from green leafy vegetables in children. Indian J. Med. Res. 71:53–56

[28] Ribaya-Mercado JD, Maramag CC, Tengco LW, et al. 2007. Carotene-rich plant foods ingested with minimal dietary fat enhance the total-body vitamin a pool size in filipino schoolchildren as assessed by stable-isotope-dilution methodology. Am. J. Clin. Nutr. 85:1041–49

[29] Borel P, Tyssandier V, Mekki N, et al. 1998. Chylomicron beta-carotene and retinyl palmitate responses are dramatically diminished when men ingest beta-carotene with medium-chain rather than long-chain triglycerides. J. Nutr. 128(8):1361–67